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Kyushu University
QM2021-0008
Animal and Cell line from human (sperm and egg)
Heterozygous Mth1-knockout mouse frozen sperms
Introduced nucleic acid: mouse Mth1 gene (7-kb EcoRI fragment containing exon 1 to 4) in which exon 3 was replaced with a pol II-neo-poly(A) cassette (Ref 1, 2).
Characteristics of the Mth1-knockout mouse: lacking oxidized purine nucleoside triphosphatase, predisposed to spontaneous tumorigenesis in liver, stomach and lung (Ref 3).
References
1. PNAS, 2001, 98(20):11456-11461.
2. Mol. Cell. Biol., 1993, 13, 2134-2140.
3. PNAS, 2001, 98(20):11456-11461.
The heterozygous Mth1-KO mouse line has been maintained by backcrossing to C57BL6/J Jcl mouse line for 41 generations.
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Company: Negotiable
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